Pedersen N C, Emmons R W, Selcer R, Woodie J D, Holliday T A, Weiss M
J Am Vet Med Assoc. 1978 May 1;172(9):1092-6.
Ascending paralysis developed in 3 dogs, 12 to 14 days following inoculation with a modified live virus, chicken embryo origin, low egg passage, Flury strain rabies vaccine. The paralysis began in the inoculated limb but rapidly involved both hindlimbs. Partial paresis of the forelimbs was seen several days following the hindlimb paralysis in all 3 dogs, and in 1 of these dogs the infection ascended rapidly to the brain as well. Two of the dogs recovered within 1 and 2 months, respectively, but the 3rd dog died within 5 days of the onset of paralytic signs. The fatal case was complicated by naturally acquired coincidental distemper. Serologic studies in 2 dogs and virus isolation from the 3rd dog indicated that rabies virus was the cause of the paralysis in 2 of the dogs and contributed to the disease syndrome in the 3rd dog. Virus could not be isolated from the saliva of CSF of the 2 surviving dogs. The virus isolated in the fatal case appeared to have some of the characteristics of the vaccine virus, as determined by its behavior in mice, cell culture, and embryonating chicken eggs and by its failure to produce Negri bodies in the brain of the infected dog.
3只犬在接种鸡胚源、低代鸡胚传代、Flury株狂犬病减毒活疫苗后12至14天出现上行性麻痹。麻痹始于接种肢体，但迅速累及双后肢。所有3只犬在后肢麻痹数天后均出现前肢部分轻瘫，其中1只犬感染还迅速蔓延至脑部。2只犬分别在1个月和2个月内恢复，但第3只犬在出现麻痹症状后5天内死亡。这例致命病例并发了自然感染的犬瘟热。对2只犬的血清学研究以及从第3只犬分离病毒表明，狂犬病病毒是其中2只犬麻痹的病因，且在第3只犬的疾病综合征中起作用。在2只存活犬的唾液或脑脊液中未分离到病毒。在致命病例中分离出的病毒，通过其在小鼠、细胞培养和鸡胚中的表现以及在感染犬脑中未产生内基氏小体，似乎具有一些疫苗病毒的特征。
