Brannstrom M, Lindskog S, Nordenvall K J
J Am Dent Assoc. 1984 Nov;109(5):735-6. doi: 10.14219/jada.archive.1984.0172.
Periodontal ligament anesthesia was applied to 16 primary teeth in jaw quadrants of two monkeys. The teeth in the contralateral positions were not injected and the permanent teeth in this area served as controls. The animals were killed after 22 months when the permanent incisors began to erupt. In total, enamel hypoplasia or hypomineralization (or both) was noticed in 15 permanent teeth in the experimental quadrants but in none of the controls. The results strongly emphasized that periodontal ligament anesthesia should be used with great care on primary teeth close to developing permanent teeth.
对两只猴子颌骨象限内的16颗乳牙进行了牙周膜麻醉。对侧位置的牙齿未注射，该区域的恒牙作为对照。在22个月后，当恒牙开始萌出时，将动物处死。总共，在实验象限的15颗恒牙中发现了釉质发育不全或矿化不足（或两者皆有），但对照牙齿中均未发现。结果强烈强调，在靠近正在发育的恒牙的乳牙上使用牙周膜麻醉时应格外小心。
