Taylor W M
J Clin Psychiatry. 1978 Jun;39(6):499-503.
Rheumatoid arthritis and schizophrenia have been described in early surveys as mutually exclusive disorders. Such claims are seen as especially interesting in view of: (1) indications that both illnesses often follow prodromes of severe psychological stress, (2) theories regarding hypermethylation of indoleamines producing endogenous psychotogens in schizophrenia, and (3) studies of rheumatoid arthritis reporting excessive binding of L-tryptophan to plasma protein, abnormalities of urinary tryptophan metabolites, decreased serotonin binding capacity of thrombocytes, and decreased MAO activity in joint fluid. Further comparative studies of tryptophan metabolism in schizophrenia and rheumatoid arthritis might enhance knowledge of pathogenesis in either or both diseases.
在早期调查中，类风湿性关节炎和精神分裂症被描述为相互排斥的疾病。鉴于以下几点，这些说法显得尤为有趣：（1）有迹象表明这两种疾病通常都伴有严重心理压力的前驱症状；（2）关于吲哚胺高甲基化在精神分裂症中产生内源性精神致幻剂的理论；（3）对类风湿性关节炎的研究报告称，L-色氨酸与血浆蛋白的结合过多、尿色氨酸代谢产物异常、血小板的血清素结合能力下降以及关节液中MAO活性降低。进一步对精神分裂症和类风湿性关节炎患者的色氨酸代谢进行比较研究，可能会增进对这两种疾病或其中一种疾病发病机制的了解。
