Granholm A C
Scand J Dent Res. 1984 Oct;92(5):381-90. doi: 10.1111/j.1600-0722.1984.tb00906.x.
Rat molar and incisor tooth germs from gestational days 18-21 were homologously grafted to the anterior eye chamber of adult recipients. The fetal tooth transplants survived and grew considerably in the eye, attached to and vascularized from the anterior surface of the host iris. Grafts were examined histologically and compared with in situ controls after up to 6 months in oculo. Radiographic examinations of the grafts showed a normal rate of mineralization and a distinct enamel/dentin border after intraocular development. The size of the tooth grafts was somewhat smaller than in situ but the grafted teeth attained a form much resembling in situ incisors and molars. Light microscopy revealed a regular dentin and predentin, a distinct dentin/enamel border and a well innervated and vascularized pulp. No degenerative changes in dentin or enamel layers could be found in long-term grafts (6 months). Thus, intraocular tooth grafts in rats develop many histologic and anatomic features typical of normal teeth, emphasizing the importance of intrinsic regulatory mechanisms in tooth development.
将妊娠第18 - 21天的大鼠磨牙和切牙牙胚同源移植到成年受体的眼前房。胎儿牙齿移植在眼中存活并显著生长，附着于宿主虹膜前表面并由此血管化。对移植物进行组织学检查，并与眼内长达6个月的原位对照进行比较。对移植物的放射学检查显示，眼内发育后矿化速率正常，釉质/牙本质边界清晰。牙齿移植物的大小比原位略小，但移植的牙齿形态与原位切牙和磨牙非常相似。光学显微镜检查显示有规则的牙本质和前期牙本质、明显的牙本质/釉质边界以及神经和血管丰富的牙髓。长期移植物（6个月）中未发现牙本质或釉质层的退行性变化。因此，大鼠眼内牙齿移植发育出许多正常牙齿典型的组织学和解剖学特征，强调了牙齿发育中内在调节机制的重要性。
