Koskimies A I, Tenhunen A, Ylikorkala O
Acta Obstet Gynecol Scand Suppl. 1984;123:19-21. doi: 10.3109/00016348409156975.
To study peritoneal fluid (PF) prostaglandin (PG) in infertile women, 6-keto-PGF1 alpha (a breakdown product of prostacyclin) and thromboxane B2 (T X B2) (a metabolite of T X A2) were assayed with radio-immunoassays from PF samples collected at laparascopy from patients with endometriosis (n = 29), unexplained infertility (n = 13) and from women with normal pelvic organs (n = 25). The concentrations of 6-keto-PGF1 alpha and T X B2 in PF were increased (p less than 0.05) in endometriosis and unexplained infertility, as compared with the corresponding levels in the controls. In patients with endometriosis, both 6-keto-PGF1 alpha and T X B2 increases were related to the severity of the disease. There was no relationship between 6-keto-PGF1 alpha/T X B2 in PF, and day of menstrual cycle. It is suggested that endometriotic tissue and peritoneal macrophages may contribute to these prostanoids in PF. The smooth muscle activities of PF prostacyclin and T X A2 may be involved in infertility by interfering with tubal function.
为研究不孕女性的腹腔液（PF）前列腺素（PG），采用放射免疫分析法对子宫内膜异位症患者（n = 29）、不明原因不孕症患者（n = 13）以及盆腔器官正常女性（n = 25）在腹腔镜检查时采集的PF样本中的6 - 酮 - 前列环素F1α（前列环素的降解产物）和血栓素B2（血栓素A2的代谢产物）进行了检测。与对照组相应水平相比，子宫内膜异位症和不明原因不孕症患者PF中6 - 酮 - 前列环素F1α和血栓素B2的浓度升高（p < 0.05）。在子宫内膜异位症患者中，6 - 酮 - 前列环素F1α和血栓素B2的升高均与疾病严重程度相关。PF中6 - 酮 - 前列环素F1α/血栓素B2与月经周期天数之间无相关性。提示子宫内膜异位组织和腹腔巨噬细胞可能是PF中这些前列腺素的来源。PF中前列环素和血栓素A2的平滑肌活性可能通过干扰输卵管功能而与不孕有关。
