McCabe J T, Leibowitz S F
Brain Res. 1984 Oct 8;311(2):211-24. doi: 10.1016/0006-8993(84)90085-4.
Previous studies suggest that brainstem catecholamine (CA) fibers which mediate amphetamine (AMPH)-induced anorexia ascend through the midlateral medical forebrain bundle and perifornical region and terminate in the perifornical hypothalamic region (PFH) at the level of the hypothalamic ventromedial nucleus. Through studies of wire-knife cuts (KCs) placed in the lower brainstem, the present paper further delineates the course of fibers mediating AMPH feeding suppression, as they ascend through the medullary, pontine and midbrain tegmentum. The results indicate that the crucial CA fibers ascend through the ventrolateral medulla just dorsal to the nucleus of the seventh cranial nerve, 1.1-1.9 mm lateral to midline. In their rostral course, these fibers apparently maintain a relatively straight position in the ventral pons and then enter the ventrolateral midbrain just dorsal to the medial lemniscus, between 0.7 and 1.1 mm lateral to midline. These medullary fibers, possibly originating from the norepinephrine/epinephrine-containing ventrolateral cell group (A1/C1), then appear to join additional fibers from the scattered dopamine-containing neurons positioned in the caudal midbrain (A8 CA cell group). Together, these dopamine, epinephrine and norepinephrine systems are believed to ascend into the medial aspect of the medial forebrain bundle on their way to the PFH at the level of the ventromedial nucleus.
先前的研究表明，介导苯丙胺（AMPH）所致厌食的脑干儿茶酚胺（CA）纤维通过中外侧内侧前脑束和穹窿周区上行，并在下丘脑腹内侧核水平的穹窿周下丘脑区（PFH）终止。通过对置于脑干下部的线刀切割（KC）的研究，本文进一步描绘了介导AMPH抑制进食的纤维在通过延髓、脑桥和中脑被盖上行时的路径。结果表明，关键的CA纤维在第七脑神经核背侧的延髓腹外侧上行，距中线外侧1.1 - 1.9毫米。在其向头端的行程中，这些纤维在脑桥腹侧明显保持相对笔直的位置，然后进入内侧丘系背侧的中脑腹外侧，距中线外侧0.7至1.1毫米。这些延髓纤维可能起源于含去甲肾上腺素/肾上腺素的腹外侧细胞群（A1/C1），然后似乎与来自位于尾侧中脑的散在含多巴胺神经元（A8 CA细胞群）的其他纤维会合。据信，这些多巴胺、肾上腺素和去甲肾上腺素系统在前往腹内侧核水平的PFH的途中，一起上行进入内侧前脑束的内侧部分。
