维拉帕米增强阿霉素对人髓性白血病细胞的体外细胞毒性作用。
In vitro enhancement of adriamycin cytotoxicity in human myeloid leukemia cells exposed to verapamil.
作者信息
Pradhan S G, Basrur V S, Chitnis M P, Adwani S H
出版信息
Oncology. 1984;41(6):406-8. doi: 10.1159/000225865.
PMID:6594649
Abstract
The natural resistance of human chronic myeloid leukemia cells to adriamycin (ADR) was overcome by using the cell membrane modulator verapamil (VRP). The studies were done in vitro. [3H] thymidine incorporation inhibition was used as a measure of cytotoxicity. The results clearly show an increase in the effectiveness of ADR when used along with VRP, which may be due to the changes in the cell membrane brought about by VRP.
摘要
通过使用细胞膜调节剂维拉帕米（VRP）克服了人类慢性髓性白血病细胞对阿霉素（ADR）的天然耐药性。这些研究是在体外进行的。采用[3H]胸腺嘧啶核苷掺入抑制法作为细胞毒性的检测指标。结果清楚地表明，ADR与VRP联合使用时有效性增加，这可能是由于VRP引起的细胞膜变化所致。
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