维生素B6对大鼠脑内γ-氨基丁酸水平的影响。

Effect of vitamin B6 on gamma-aminobutyric acid level in rat brain.

作者信息

Vukadinović V R, Rakić L M

出版信息

Arch Int Physiol Biochim. 1976 Oct;84(4):753-8. doi: 10.3109/13813457609067049.

DOI:10.3109/13813457609067049

PMID:65950

Abstract

Vitamin B6 injected intraperitoneally into rats 400 mg/kg body weight, has produced a statistically significant decrease in GABA level concentrations in hippocampus and cerebellum. Cerebral cortex, caudate nucleus and thalamus have shown the decrease in GABA concentrations, but these changes were not statistically significant. No remarkable behavioural changes were noted under such circumstances. The possible functional meaning of these results is discussed in relation to the role of GABA distribution in different brain regions and development of convulsions.

摘要

以400毫克/千克体重的剂量给大鼠腹腔注射维生素B6后，海马体和小脑中的γ-氨基丁酸（GABA）水平浓度出现了具有统计学意义的下降。大脑皮层、尾状核和丘脑的GABA浓度也有所下降，但这些变化没有统计学意义。在这种情况下未观察到明显的行为变化。结合GABA在不同脑区的分布作用及惊厥的发展，对这些结果可能的功能意义进行了讨论。

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