甲氯芬那酸钠对放射性食管炎和膀胱炎的影响。
Effect of sodium meclofenamate on radiation-induced esophagitis and cystitis.
作者信息
Ambrus J L, Ambrus C M, Lillie D B, Johnson R J, Gastpar H, Kishel S
出版信息
J Med. 1984;15(2):81-92.
PMID:6595342
Abstract
Stumptailed monkeys (Macaca arctoides) received 2000 rad irradiation to the upper half of the esophagus and to the bladder by a 6-MEV linear accelerator. Endoscopy and biopsy was obtained from these organs weekly for 3 weeks. At the end of this period, the animals were autopsied and histopathologic examination undertaken. Sodium meclofenamate in doses of 5-20 mg/kg/day p.os was found effective in reducing or preventing radiation induced esophagitis and cystitis.
摘要
将断尾猴（熊猴）用一台6兆电子伏直线加速器对其食管上半段和膀胱进行2000拉德的照射。连续3周每周对这些器官进行内镜检查并活检。在此阶段结束时，对动物进行尸检并进行组织病理学检查。发现口服剂量为5 - 20毫克/千克/天的甲氯芬那酸钠可有效减轻或预防放射性食管炎和膀胱炎。
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