Johnston A, McHaffie D
J Chromatogr. 1978 May 21;152(2):501-6. doi: 10.1016/s0021-9673(00)85087-6.
A rapid, sensitive and specific gas-liquid chromatographic method is presented for the routine monitoring of plasma concentrations of the anti-arrhythmic compound, disopyramide. The procedure involves extraction of the drug from alkaline plasma into ether, purification of the extract and gas chromatographic analysis using OV-101 liquid phase and flame ionization detection. The results demonstrate the accuracy and reproducibility of the method. Contrary to a previous report, it has been shown that delay in separating plasma from erythrocytes does not affect the disopyramide level in plasma.
本文介绍了一种快速、灵敏且特异的气液色谱法，用于常规监测抗心律失常化合物丙吡胺的血浆浓度。该方法包括从碱性血浆中提取药物至乙醚中，对提取物进行纯化，并使用OV-101固定相和火焰离子化检测进行气相色谱分析。结果证明了该方法的准确性和可重复性。与先前的报告相反，已表明延迟从红细胞中分离血浆不会影响血浆中丙吡胺的水平。
