Jensen K M
J Chromatogr. 1978 Jun 1;153(1):195-202. doi: 10.1016/s0021-9673(00)89872-6.
A method for determining indomethacin in serum has been developed, involving extractive alkylation, in which indomethacin is converted into its ethyl ester, and subsequent gas chromatographic determination of the ester. The method is specific and permits the determination of amounts down to 50 ng/ml in serum. The indomethacin concentration in serum was followed for 24 h after oral and rectal application and the results are compared with those reported in the literature.
已开发出一种测定血清中吲哚美辛的方法，该方法包括萃取烷基化，即将吲哚美辛转化为其乙酯，随后对该酯进行气相色谱测定。该方法具有特异性，能够测定血清中低至50纳克/毫升的含量。在口服和直肠给药后，对血清中吲哚美辛的浓度进行了24小时的跟踪，并将结果与文献报道的结果进行了比较。
