Solas J, Marx O, Jagailloux J L, Bonduelle M
Rev Stomatol Chir Maxillofac. 1984;85(5):441-3.
The chemotherapy schedule used for treatment of epidermoid carcinoma of the buccal cavity is described, together with the technique proposed by Richard for introduction of the intra-arterial catheters. Two sessions of intra-arterial infusion lasting 6 days are separated by an treatment-free interval of 6 days. Five patients with oropharyngeal endobuccal epithelioma were treated in this way, two of these cases receiving major surgery during chemotherapy. Analysis of a pelvimandibulectomy operative specimen from one of these patients failed to show any trace of cancer in a lesion which had been initially classified T3N3 by histology. This case, combined with other reports of clinical remission without histologic proof, and after a short follow up, suggests a certain efficacy for cisplatinum intra-arterially. This local efficacy, without however diminishing the surgical target volume, will probably give a better survival rate than when surgery alone is performed.
本文描述了用于治疗颊腔表皮样癌的化疗方案，以及理查德提出的动脉内导管插入技术。两次为期6天的动脉内输注疗程之间间隔6天的无治疗期。5例口咽颊内上皮瘤患者接受了这种治疗，其中2例在化疗期间接受了大手术。对其中1例患者的骨盆下颌骨切除术手术标本进行分析，结果显示，最初经组织学分类为T3N3的病变中未发现任何癌症痕迹。该病例与其他无组织学证据的临床缓解报告相结合，且经过短期随访，提示动脉内注射顺铂具有一定疗效。这种局部疗效，在不减小手术靶体积的情况下，可能比单纯手术能带来更好的生存率。
