阑尾切除术前切口周围给药后血浆和组织中头孢美唑的浓度。
Concentrations of cefmetazole in plasma and tissue resulting from peri-incisional administration before appendectomy.
作者信息
Rodríguez J R, Mariño E L, Otero M J, Commes J R, Garcia J, Rodriguez J M, Lozano F, Dominguez-Gil A, Alonso A G
出版信息
Antimicrob Agents Chemother. 1984 Nov;26(5):787-8. doi: 10.1128/AAC.26.5.787.
The levels of cefmetazole in plasma and tissue were determined after injection of a dose of 30 mg/kg into the zone of the wound of each of 15 patients undergoing appendectomy. The mean plasma levels of cefmetazole at the start and end of surgery (8.9 +/- 2.4 and 31.7 +/- 6.4 min after dosage) were 21.1 and 59.0 micrograms/ml, respectively; concentrations of the drug were 14.6 and 4,486.9 micrograms/g in skin, 9,165.0 and 1,756.4 micrograms/g in subcutaneous tissue, and 8,669.6 and 2,022.9 micrograms/g in muscle.
对15例接受阑尾切除术的患者，在其伤口部位注射30mg/kg剂量的头孢美唑后，测定血浆和组织中的头孢美唑水平。手术开始和结束时（给药后8.9±2.4分钟和31.7±6.4分钟）头孢美唑的平均血浆水平分别为21.1和59.0微克/毫升；皮肤中药物浓度分别为14.6和4486.9微克/克，皮下组织中为9165.0和1756.4微克/克，肌肉中为8669.6和2022.9微克/克。
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