Karhunen P J, Penttilä A, Liesto K, Männikkö A, Välimäki M, Möttönen M, Ylikahri R
Arch Toxicol Suppl. 1984;7:155-8. doi: 10.1007/978-3-642-69132-4_20.
The weight of testicles and morphometric changes in testicular germinal tissue and Leydig cells were correlated with chronic consumption of ethyl alcohol and liver diseases in 44 consecutive autopsies. The mass and volume of seminiferous tubules decreased with the increase in alcohol consumption (p less than 0.05). The atrophy and fibrosis of testicles were most advanced in males with liver cirrhosis (p less than 0.005) and in males with moderate or heavy fatty liver (p less than 0.01) whereas these parameters were only slightly decreased in alcoholic males with normal liver despite the greater amount of ethanol consumed. The changes in Leydig cells were mainly inconspicious. These results indicate that the most sensitive tissue to chronic alcohol-induced injury in testis is the germinal tissue and point out the role of liver diseases in testicular damage found in alcoholics.
在44例连续尸检中，研究了睾丸重量以及睾丸生精组织和间质细胞的形态计量学变化与长期乙醇摄入及肝脏疾病的相关性。随着酒精摄入量的增加，生精小管的质量和体积减小（p<0.05）。睾丸萎缩和纤维化在肝硬化男性（p<0.005）以及中度或重度脂肪肝男性中最为严重（p<0.01），而尽管饮酒量更大，但肝脏正常的酒精性男性中这些参数仅略有下降。间质细胞的变化主要不明显。这些结果表明，睾丸中对慢性酒精诱导损伤最敏感的组织是生精组织，并指出了肝脏疾病在酒精性肝病患者睾丸损伤中的作用。
