丙烯腈与肝脏混合功能氧化酶的相互作用。

Interaction of acrylonitrile with the liver mixed function oxidases.

作者信息

Cova D, Chiesara E, Rizzi R

出版信息

Arch Toxicol Suppl. 1984;7:291-4. doi: 10.1007/978-3-642-69132-4_47.

Abstract

The effect on the liver mixed function oxidases of acrylonitrile revealed an inhibition of the benzo(a)pyrene hydroxylase and of the epoxide hydrase whereas aniline hydroxylase is unaffected. These findings exclude the possibility that the inhibitory effect of certain hydroxylation activities of the liver microsomes can be secondary to a direct effect of acrylonitrile on cytochrome P-450 but suggest the hypothesis that the inhibition is mediated by the cyanide released during acrylonitrile metabolism.

摘要

丙烯腈对肝脏混合功能氧化酶的影响显示，它抑制了苯并(a)芘羟化酶和环氧化物水化酶，而苯胺羟化酶未受影响。这些发现排除了肝脏微粒体某些羟基化活性的抑制作用可能继发于丙烯腈对细胞色素P - 450的直接作用的可能性，但提出了一种假说，即这种抑制作用是由丙烯腈代谢过程中释放的氰化物介导的。