De Sarro G B, Donato A, Bagetta G, Pujia A, Nisticò G
Arch Toxicol Suppl. 1984;7:420-4. doi: 10.1007/978-3-642-69132-4_78.
The effects of patulin when given into the third cerebral ventricle of rats, on behaviour and electrocortical spectrum power have been investigated. Patulin (10 micrograms i.v.t.) produced behavioural sedation, hypoalgesia, tail rigidity, piloerection and postural changes. This symptomatology lasted approx. 3 h and was accompanied by slower frequency and larger amplitude potentials in the electrocorticogram (ECoG) and by an increase in total voltage power. A larger dose (50 micrograms) produced a more dramatic picture characterized by catatonic posture with kyphosis, loss of the righting reflex, tail rigidity and on a few occasions short-duration episodes of tonic-clonic convulsions. Such a symptomatology was accompanied by a flattening of ECoG activity with a significant fall in total voltage power, as well as in preselected bands (0-3, 3-6, 6-9, 9-12, and 12-16 Hz). A lower dose (1 microgram) of patulin, on the other hand, produced behavioural sedation without significant changes in ECoG spectrum power.
研究了棒曲霉素注入大鼠第三脑室后对行为和皮层电图频谱功率的影响。棒曲霉素（静脉注射10微克）引起行为镇静、痛觉减退、尾部僵硬、竖毛和姿势改变。这种症状持续约3小时，同时伴有皮层电图（ECoG）中频率减慢和电位幅度增大，以及总电压功率增加。较大剂量（50微克）产生更显著的症状，表现为脊柱后凸的紧张性姿势、翻正反射丧失、尾部僵硬，少数情况下还出现短暂的强直阵挛性惊厥发作。这种症状伴有ECoG活动的平坦化，总电压功率以及预选频段（0 - 3、3 - 6、6 - 9、9 - 12和12 - 16赫兹）的功率显著下降。另一方面，较低剂量（1微克）的棒曲霉素引起行为镇静，但ECoG频谱功率无显著变化。
