Nisticò G, De Sarro G B, Bagetta G, Müller E E
Neuropharmacology. 1987 Jan;26(1):75-8. doi: 10.1016/0028-3908(87)90047-5.
The effects on behaviour and electrocortical spectrum power of intracerebroventricular, intrahippocampal and intracaudate injections of human pancreatic growth hormone releasing Factor-40 (hpGRF) (10-100 ng) were studied in rats. The hpGRF, given into the third cerebral ventricle or into the dorsal hippocampus (50-100 ng), in freely-moving rats, produced behavioural sedation accompanied by electrocortical synchronization and an increase in the total voltage power with a predominant increase in the lower frequency bands. On the contrary, unilateral injection of hpGRF (75 ng) into the head of the caudate nucleus produced an increase in locomotor activity, marked postural changes, episodes of contralateral circling and an intense pattern of stereotyped movements. In all, these results indicate that, besides its specific endocrinological effects, hpGRF possesses, in small doses, marked behavioural and electrocortical actions, the mechanism(s) of which still remain to be elucidated.
研究了向大鼠脑室内、海马内和尾状核内注射人胰腺生长激素释放因子40（hpGRF）（10 - 100纳克）对其行为和脑电皮质频谱功率的影响。在自由活动的大鼠中，将hpGRF注入第三脑室或背侧海马（50 - 100纳克）会产生行为镇静，伴有脑电皮质同步化以及总电压功率增加，低频带功率增加尤为明显。相反，向尾状核头部单侧注射hpGRF（75纳克）会导致运动活动增加、明显的姿势改变、对侧转圈发作以及强烈的刻板运动模式。总之，这些结果表明，除了其特定的内分泌作用外，小剂量的hpGRF还具有明显的行为和脑电皮质作用，其作用机制仍有待阐明。
