螺内酯。一种刺激乌龟膀胱分泌氢离子的醛固酮激动剂。
Spironolactone. An aldosterone agonist in the stimulation of H+ secretion by turtle urinary bladder.
作者信息
Mueller A, Steinmetz P R
出版信息
J Clin Invest. 1978 Jun;61(6):1666-70. doi: 10.1172/JCI109087.
Abstract
In the isolated turtle bladder, spironolactone inhibits sodium transport in the presence of aldosterone or endogenous mineralocorticoid hormone. In contrast to this antagonism for the stimulation of sodium transport by aldosterone, the stimulation of hydrogen ion secretion by aldosterone is not inhibited by spironolactone. In hormone-depleted bladders, spironolactone stimulates hydrogen ion secretion. The extent of stimulation is similar to that of aldosterone. Spironolactone functions as an agonist for aldosterone for the stimulation of urinary acidification.
摘要
在离体龟膀胱中，螺内酯在有醛固酮或内源性盐皮质激素存在的情况下抑制钠转运。与对醛固酮刺激钠转运的这种拮抗作用相反，醛固酮刺激氢离子分泌不受螺内酯抑制。在激素缺乏的膀胱中，螺内酯刺激氢离子分泌。刺激程度与醛固酮相似。螺内酯作为醛固酮的激动剂发挥作用以刺激尿液酸化。
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本文引用的文献
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DECREASED EFFECTIVENESS OF ALDOSTERONE ON ACTIVE SODIUM TRANSPORT BY THE ISOLATED TOAD BLADDER IN THE PRESENCE OF OTHER STEROIDS.在其他类固醇存在的情况下，醛固酮对离体蟾蜍膀胱主动钠转运的有效性降低。
Acta Endocrinol (Copenh). 1964 Nov;47:419-32. doi: 10.1530/acta.0.0470419.
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Action of new steroids in blocking effects of aldosterone and desoxycorticosterone on salt.新型类固醇在阻断醛固酮和脱氧皮质酮对盐的作用方面的效果
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Independence of hydrogen ion secretion and transport of other electrolytes in turtle bladder.龟膀胱中氢离子分泌与其他电解质转运的独立性
J Clin Invest. 1967 Oct;46(10):1541-8. doi: 10.1172/JCI105645.
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Characteristics of hydrogen ion transport in urinary bladder of water turtle.水龟膀胱中氢离子转运的特征
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Studies on the binding of aldosterone in the toad bladder.蟾蜍膀胱中醛固酮结合情况的研究。
J Clin Invest. 1966 Apr;45(4):450-9. doi: 10.1172/JCI105359.
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Physiol Rev. 1966 Oct;46(4):593-633. doi: 10.1152/physrev.1966.46.4.593.
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