Mueller A, Steinmetz P R
J Clin Invest. 1978 Jun;61(6):1666-70. doi: 10.1172/JCI109087.
In the isolated turtle bladder, spironolactone inhibits sodium transport in the presence of aldosterone or endogenous mineralocorticoid hormone. In contrast to this antagonism for the stimulation of sodium transport by aldosterone, the stimulation of hydrogen ion secretion by aldosterone is not inhibited by spironolactone. In hormone-depleted bladders, spironolactone stimulates hydrogen ion secretion. The extent of stimulation is similar to that of aldosterone. Spironolactone functions as an agonist for aldosterone for the stimulation of urinary acidification.
在离体龟膀胱中,螺内酯在有醛固酮或内源性盐皮质激素存在的情况下抑制钠转运。与对醛固酮刺激钠转运的这种拮抗作用相反,醛固酮刺激氢离子分泌不受螺内酯抑制。在激素缺乏的膀胱中,螺内酯刺激氢离子分泌。刺激程度与醛固酮相似。螺内酯作为醛固酮的激动剂发挥作用以刺激尿液酸化。