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螺内酯。一种刺激乌龟膀胱分泌氢离子的醛固酮激动剂。

Spironolactone. An aldosterone agonist in the stimulation of H+ secretion by turtle urinary bladder.

作者信息

Mueller A, Steinmetz P R

出版信息

J Clin Invest. 1978 Jun;61(6):1666-70. doi: 10.1172/JCI109087.

DOI:10.1172/JCI109087
PMID:659620
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC372693/
Abstract

In the isolated turtle bladder, spironolactone inhibits sodium transport in the presence of aldosterone or endogenous mineralocorticoid hormone. In contrast to this antagonism for the stimulation of sodium transport by aldosterone, the stimulation of hydrogen ion secretion by aldosterone is not inhibited by spironolactone. In hormone-depleted bladders, spironolactone stimulates hydrogen ion secretion. The extent of stimulation is similar to that of aldosterone. Spironolactone functions as an agonist for aldosterone for the stimulation of urinary acidification.

摘要

在离体龟膀胱中，螺内酯在有醛固酮或内源性盐皮质激素存在的情况下抑制钠转运。与对醛固酮刺激钠转运的这种拮抗作用相反，醛固酮刺激氢离子分泌不受螺内酯抑制。在激素缺乏的膀胱中，螺内酯刺激氢离子分泌。刺激程度与醛固酮相似。螺内酯作为醛固酮的激动剂发挥作用以刺激尿液酸化。

相似文献

1
Spironolactone. An aldosterone agonist in the stimulation of H+ secretion by turtle urinary bladder.螺内酯。一种刺激乌龟膀胱分泌氢离子的醛固酮激动剂。
J Clin Invest. 1978 Jun;61(6):1666-70. doi: 10.1172/JCI109087.
2
Characteristics of stimulation of H+ transport by aldosterone in turtle urinary bladder.醛固酮对玳瑁膀胱中H⁺转运的刺激特性
J Clin Invest. 1976 Aug;58(2):351-8. doi: 10.1172/JCI108479.
3
The effects of amiloride and ouabain on urinary acidification by turtle bladder.氨氯吡脒和哇巴因对龟膀胱尿液酸化作用的影响。
J Pharmacol Exp Ther. 1979 Aug;210(2):264-8.
4
In vitro inhibition of aldosterone-stimulated sodium transport by steroidal spirolactones.甾体类螺内酯对醛固酮刺激的钠转运的体外抑制作用。
Mol Pharmacol. 1968 May;4(3):224-37.
5
Independence of hydrogen ion secretion and transport of other electrolytes in turtle bladder.龟膀胱中氢离子分泌与其他电解质转运的独立性
J Clin Invest. 1967 Oct;46(10):1541-8. doi: 10.1172/JCI105645.
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Spirolactone inhibition of aldosterone induced nuclear RNA synthesis in toad urinary bladder.螺内酯对蟾蜍膀胱中醛固酮诱导的核RNA合成的抑制作用。
Res Commun Chem Pathol Pharmacol. 1970 May;1(3):363-9.
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Effect of aldosterone on the coupling between H+ transport and glucose oxidation.醛固酮对氢离子转运与葡萄糖氧化之间偶联作用的影响。
J Clin Invest. 1977 Dec;60(6):1240-7. doi: 10.1172/JCI108883.
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Inhibition of sodium transport by hyperbaric oxygen in the toad urinary bladder.高压氧对蟾蜍膀胱钠转运的抑制作用。
Undersea Biomed Res. 1977 Dec;4(4):333-45.
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Diuretics stimulate H+ secretion in turtle urinary bladder.利尿剂刺激龟膀胱中的氢离子分泌。
J Clin Invest. 1980 May;65(5):1095-103. doi: 10.1172/JCI109762.
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Inhibition of H+ secretion in the turtle bladder by colchicine and vinblastine.秋水仙碱和长春花碱对龟膀胱中氢离子分泌的抑制作用。
J Lab Clin Med. 1980 Sep;96(3):450-9.

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Bicarbonate reabsorption in the papillary collecting duct of rats.大鼠乳头集合管中的碳酸氢盐重吸收
Pflugers Arch. 1981 Mar;389(3):271-5. doi: 10.1007/BF00584789.
2
Enhancement of electrogenic Na+ transport across rat inner medullary collecting duct by glucocorticoid and by mineralocorticoid hormones.糖皮质激素和盐皮质激素对大鼠内髓集合管电生性钠转运的增强作用。
J Clin Invest. 1990 Aug;86(2):498-506. doi: 10.1172/JCI114736.

本文引用的文献

1
DECREASED EFFECTIVENESS OF ALDOSTERONE ON ACTIVE SODIUM TRANSPORT BY THE ISOLATED TOAD BLADDER IN THE PRESENCE OF OTHER STEROIDS.在其他类固醇存在的情况下，醛固酮对离体蟾蜍膀胱主动钠转运的有效性降低。
Acta Endocrinol (Copenh). 1964 Nov;47:419-32. doi: 10.1530/acta.0.0470419.
2
Action of new steroids in blocking effects of aldosterone and desoxycorticosterone on salt.新型类固醇在阻断醛固酮和脱氧皮质酮对盐的作用方面的效果
Science. 1957 Nov 15;126(3281):1015-6. doi: 10.1126/science.126.3281.1015.
3
Independence of hydrogen ion secretion and transport of other electrolytes in turtle bladder.龟膀胱中氢离子分泌与其他电解质转运的独立性
J Clin Invest. 1967 Oct;46(10):1541-8. doi: 10.1172/JCI105645.
4
Characteristics of hydrogen ion transport in urinary bladder of water turtle.水龟膀胱中氢离子转运的特征
J Clin Invest. 1967 Oct;46(10):1531-40. doi: 10.1172/JCI105644.
5
Studies on the binding of aldosterone in the toad bladder.蟾蜍膀胱中醛固酮结合情况的研究。
J Clin Invest. 1966 Apr;45(4):450-9. doi: 10.1172/JCI105359.
6
In vitro inhibition of aldosterone-stimulated sodium transport by steroidal spirolactones.甾体类螺内酯对醛固酮刺激的钠转运的体外抑制作用。
Mol Pharmacol. 1968 May;4(3):224-37.
7
Mechanism of action of aldosterone.醛固酮的作用机制。
Physiol Rev. 1966 Oct;46(4):593-633. doi: 10.1152/physrev.1966.46.4.593.
8
CO2 requirements for H+ secretion by the isolated turtle bladder.离体龟膀胱分泌氢离子对二氧化碳的需求
Am J Physiol. 1971 Jun;220(6):2051-7. doi: 10.1152/ajplegacy.1971.220.6.2051.
9
Subcellular mechanisms in the action of adrenal steroids.肾上腺类固醇作用中的亚细胞机制。
Am J Med. 1972 Nov;53(5):545-60. doi: 10.1016/0002-9343(72)90152-0.
10
Studies on the mechanism of action of aldosterone: hormone-induced changes in lipid metabolism.醛固酮作用机制的研究：激素诱导的脂质代谢变化。
Biochemistry. 1971 Oct 12;10(21):3825-31. doi: 10.1021/bi00797a004.