Miller J H, Mendoza S A
Undersea Biomed Res. 1977 Dec;4(4):333-45.
In the isolated toad bladder, 2--10 ATA of oxygen reversibly inhibited the active transport of sodium ions across the bladder, measured as the short-circuit current. Extent of inhibition was dependent on the oxygen pressure and length of exposure. Oxygen at 1 ATA had no effect on sodium transport for up to 2 days of exposure. However, bladders exposed for 18 h to oxygen at 1 ATA were more sensitive to a subsequent exposure to hyperbaric oxygen. The hormonal stimulation of sodium transport by pitressin or aldosterone was inhibited by hyperbaric oxygen but was unaffected by prolonged exposure to oxygen at 1 ATA. Incubation of bladders with aldosterone or sodium pyruvate increased the sensitivity of sodium transport to the inhibitory effects of hyperbaric oxygen. The mechanism of the inhibition of sodium transport in the toad bladder by hyperbaric oxygen was not known.
在离体蟾蜍膀胱中，2至10个绝对大气压的氧气可可逆性抑制钠离子跨膀胱的主动转运，以短路电流作为衡量指标。抑制程度取决于氧分压和暴露时间。1个绝对大气压的氧气在暴露长达2天的时间内对钠转运无影响。然而，暴露于1个绝对大气压氧气18小时的膀胱对随后的高压氧暴露更为敏感。加压素或醛固酮对钠转运的激素刺激作用被高压氧抑制，但长时间暴露于1个绝对大气压的氧气则无影响。用醛固酮或丙酮酸钠孵育膀胱可增加钠转运对高压氧抑制作用的敏感性。高压氧抑制蟾蜍膀胱钠转运的机制尚不清楚。
