Faber O K, Hagen C, Binder C, Markussen J, Naithani V K, Blix P M, Kuzuya H, Horwitz D L, Rubenstein A H, Rossing N
J Clin Invest. 1978 Jul;62(1):197-203. doi: 10.1172/JCI109106.
The metabolic clearance rate (MCR) of synthetic human connecting peptide (C-peptide) was measured with a single-dose injection technique in six normal and seven diabetic subjects and with a constant infusion technique in one normal subject. The MCR of C-peptide did not differ in normal subjects (4.4 ml/min per kg; range, 3.7-4.9) and in diabetic subjects (4.7 ml/min per kg; range, 3.7-5.8). Employment of both techniques in one subject gave similar MCR. The average half-life of C-peptide in plasma calculated from the last 1-h period of the single-dose injection studies was longer in the insulin-dependent diabetics (42.5 min; range, 39.4-48.5) than in the normal subjects (33.5 min; range, 24.9-45.3). These results indicate that the beta-cell secretory capacity of normal and insulin-dependent diabetic subjects can be compared by measuring the C-peptide concentration in peripheral venous plasma. The difference in the half-life of C-peptide in plasma between diabetics and normals suggests an altered kinetics of the disappearance of the peptide, while the overall metabolism, as expressed by the MCR, is similar.
采用单剂量注射技术，在6名正常受试者和7名糖尿病受试者中测量了合成人连接肽（C肽）的代谢清除率（MCR）；并采用持续输注技术，在1名正常受试者中进行了测量。正常受试者（4.4 ml/（min·kg）；范围3.7 - 4.9）和糖尿病受试者（4.7 ml/（min·kg）；范围3.7 - 5.8）的C肽MCR无差异。在1名受试者中采用这两种技术得出的MCR相似。根据单剂量注射研究的最后1小时计算，血浆中C肽的平均半衰期在胰岛素依赖型糖尿病患者中（42.5分钟；范围39.4 - 48.5）比正常受试者（33.5分钟；范围24.9 - 45.3）更长。这些结果表明，通过测量外周静脉血浆中的C肽浓度，可以比较正常受试者和胰岛素依赖型糖尿病患者的β细胞分泌能力。糖尿病患者和正常受试者血浆中C肽半衰期的差异表明该肽消失的动力学发生了改变，而用MCR表示的整体代谢是相似的。
