Le Quan-Bui K H, Plaisant O, Leboyer M, Gay C, Kamal L, Devynck M A, Meyer P
Psychiatry Res. 1984 Oct;13(2):129-39. doi: 10.1016/0165-1781(84)90056-8.
Platelet serotonin levels were measured in several psychiatric disorders to determine whether they distinguish among major depressive disorder (one or more depressive episodes and no manic episodes), dysthymic disorder (depressive neurosis), and schizophrenic and paranoid disorders. Serotonin levels in 141 subjects were determined using high performance liquid chromatography with electrochemical detection. Serotonin (5HT) levels in control subjects were significantly lower in males than in females. A marked reduction in 5HT levels, as compared to controls, was found in male and female patients with major depressive disorder, but not in dysthymic disorder. A slight but significant reduction in serotonin levels was found in female schizophrenic patients. The reduction in serotonin levels found in major depressive disorder could not be attributed to chronic antidepressant treatment. Liquid chromatography with electrochemical detection used in the present study permits a large-scale investigation.
测量了几种精神疾病患者的血小板血清素水平，以确定这些水平是否能区分重度抑郁症（一次或多次抑郁发作且无躁狂发作）、心境恶劣障碍（抑郁性神经症）以及精神分裂症和偏执性障碍。使用高效液相色谱电化学检测法测定了141名受试者的血清素水平。对照组中，男性的血清素（5HT）水平显著低于女性。与对照组相比，重度抑郁症的男性和女性患者的5HT水平均显著降低，但心境恶劣障碍患者未出现这种情况。女性精神分裂症患者的血清素水平有轻微但显著的降低。重度抑郁症患者血清素水平的降低不能归因于长期抗抑郁治疗。本研究中使用的高效液相色谱电化学检测法允许进行大规模调查。
