Tang S W, Glaister J, Davidson L, Toth R, Jeffries J J, Seeman P
Psychiatry Res. 1984 Dec;13(4):285-93. doi: 10.1016/0165-1781(84)90076-3.
Nineteen male patients, under 35 years of age, newly admitted with a diagnosis of schizophrenia, were treated with either chlorpromazine or haloperidol at a fixed dosage for 25 days. Both total and free plasma neuroleptic levels were measured using a radioreceptor assay. Clinical response was measured by the Brief Psychiatric Rating Scale (BPRS). On day 25, nonresponders (those with a decrease of less than 8 points on the BPRS) had both total and free plasma neuroleptic levels within the range observed in responders. It is therefore concluded that lack of therapeutic response is generally not due to inadequate plasma drug levels.
19名年龄在35岁以下、新确诊为精神分裂症的男性患者，以固定剂量接受氯丙嗪或氟哌啶醇治疗25天。使用放射受体分析法测定血浆中抗精神病药物的总水平和游离水平。用简明精神病评定量表（BPRS）衡量临床反应。在第25天，无反应者（即BPRS评分下降少于8分者）血浆中抗精神病药物的总水平和游离水平均在有反应者观察到的范围内。因此得出结论，治疗反应不佳通常不是由于血浆药物水平不足所致。
