氟哌啶醇。血浆水平和催乳素反应作为精神分裂症临床改善的预测指标：化学法与放射受体血浆水平测定法

Haloperidol. Plasma levels and prolactin response as predictors of clinical improvement in schizophrenia: chemical v radioreceptor plasma level assays.

作者信息

Smith R C, Baumgartner R, Misra C H, Mauldin M, Shvartsburd A, Ho B T, DeJohn C

出版信息

Arch Gen Psychiatry. 1984 Nov;41(11):1044-9. doi: 10.1001/archpsyc.1983.01790220034006.

DOI:10.1001/archpsyc.1983.01790220034006

Abstract

The relationship between clinical response of schizophrenic patients to haloperidol and (1) blood levels of the medication, determined by both gas-liquid chromatography (GLC) and radioreceptor (RR) assays, or (2) prolactin response to the medication, was examined in an inpatient study using several fixed doses of haloperidol. Regression analysis disclosed a substantial curvilinear relationship between steady-state GLC-determined plasma haloperidol levels and decrease in Brief Psychiatric Rating Scale (BPRS) Psychosis factor scores; however, no substantial relationship was found between clinical response and RR plasma haloperidol levels or serum prolactin response to haloperidol. Our results suggest that steady-state plasma levels of haloperidol determined by the GLC chemical assay are a better predictor of decreases in BPRS Psychosis factor scores than RR assayed plasma haloperidol levels or prolactin response to haloperidol.

摘要

在一项住院患者研究中，使用几种固定剂量的氟哌啶醇，研究了精神分裂症患者对氟哌啶醇的临床反应与以下两者的关系：（1）通过气液色谱法（GLC）和放射受体（RR）测定法确定的药物血药浓度，或（2）药物引起的催乳素反应。回归分析显示，GLC测定的稳态血浆氟哌啶醇水平与简明精神病评定量表（BPRS）精神病因子评分降低之间存在显著的曲线关系；然而，未发现临床反应与RR血浆氟哌啶醇水平或氟哌啶醇引起的血清催乳素反应之间存在显著关系。我们的结果表明，与RR测定的血浆氟哌啶醇水平或氟哌啶醇引起的催乳素反应相比，GLC化学测定法确定的氟哌啶醇稳态血浆水平能更好地预测BPRS精神病因子评分的降低。