类风湿关节炎中的组织相容性抗原组合。

Histocompatibility antigen combinations in rheumatoid arthritis.

作者信息

Karsh J, Klippel J H, Mann D L, Reinertsen J L, Moutsopoulos H M, Johnson A H, Decker J L

出版信息

Clin Exp Rheumatol. 1983 Jan-Mar;1(1):11-5.

Abstract

The frequencies of HLA-A, -B, -C, DR and MT lymphocyte alloantigens in clinical and serologic subsets of rheumatoid arthritis (RA) were determined in 65 Caucasian patients with definite or classical disease and compared to frequencies observed in normal individuals. The elevation in frequency of several antigens controlled by different genes in the major histocompatibility complex (MHC) suggested that combinations of antigens may be associated with RA. Significant associations were found for HLA-A1-DR4 and A1-MT2 (p less than 0.001), Bw40-DR4 (p less than 0.002) and Cw3-DR4 (p less than 0.001). The results indicate that combinations of genes in the MHC are influential in predisposing to RA.

摘要

在65例确诊为典型类风湿关节炎（RA）的白种病人中，测定了其临床和血清学亚组中HLA - A、 - B、 - C、DR和MT淋巴细胞同种抗原的频率，并与正常个体中观察到的频率进行比较。主要组织相容性复合体（MHC）中由不同基因控制的几种抗原频率升高，提示抗原组合可能与类风湿关节炎有关。发现HLA - A1 - DR4和A1 - MT2（p＜0.001）、Bw40 - DR4（p＜0.002）和Cw3 - DR4（p＜0.001）有显著相关性。结果表明，MHC中的基因组合对类风湿关节炎的易感性有影响。