类风湿关节炎中的人类白细胞抗原DR抗原与疾病表现
HLA DR antigens and disease expression in rheumatoid arthritis.
作者信息
Griffin A J, Wooley P, Panayi G S, Batchelor J R
出版信息
Ann Rheum Dis. 1984 Apr;43(2):218-21. doi: 10.1136/ard.43.2.218.
Ninety-four patients with rheumatoid arthritis who possessed one or more of the HLA DR alloantigens 2, 3, or 4 were studied to investigate the genetic influence on disease severity and prognosis. In those with a disease duration of less than 10 years radiological damage was less in patients with DR2 than in those without this antigen. When current joint scores were compared, patients with this antigen had less evidence of disease than patients with DR3 or 4, DR3 patients having the highest scores. The presence of nodules and Sjögren's syndrome were less common in the DR2 patients. Variability in response to disease modifying drugs according to the patient's HLA DR antigen status may explain these differences. It is concluded, however, that possession of HLA DR2 may be an indicator of good prognosis in patients with rheumatoid arthritis.
对94名患有类风湿性关节炎且拥有一种或多种HLA DR同种异体抗原2、3或4的患者进行了研究，以调查基因对疾病严重程度和预后的影响。在病程少于10年的患者中，携带DR2的患者的放射学损伤比不携带该抗原的患者要少。当比较当前的关节评分时，携带该抗原的患者的疾病迹象比携带DR3或4的患者要少，DR3患者的评分最高。结节和干燥综合征在携带DR2的患者中较少见。根据患者的HLA DR抗原状态，对病情缓解药物的反应差异可能解释了这些不同。然而，可以得出结论，携带HLA DR2可能是类风湿性关节炎患者预后良好的一个指标。
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