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甲基汞中毒儿童的换血治疗

Exchange transfusion treatment of methylmercury-poisoned children.

作者信息

Elhassani S B, Amin-Zaki L, Majeed M A, Clarkson T W, Doherty R A, Greenwood M R, Kilpper R W

机构信息

University of Baghdad, Medical City, Iraq.

出版信息

J Environ Sci Health C. 1978;13(1):63-80.

PMID:659814
Abstract

Three children, ages 6 months, 13 months and 10 years were treated by exchange transfusions following exposure to methylmercury in the Iraq outbreak in 1971-72. Two had severe signs of poisoning and the other was clinically normal but had a high blood mercury concentration. Exchange transfusion resulted in clearance of mercury not only from blood but also from other tissues. The average amount of mercury removed in a two hour exchange was estimated as 6% of the body burden as compared to 1% of the body burden removed by normal excretion processes in 24 hours. No dramatic improvement in the clinical condition of the two poisoned patients occurred. Some improvement in motor power and function was observed during follow-up visits to their houses.

摘要

1971年至1972年伊拉克疫情期间,3名年龄分别为6个月、13个月和10岁的儿童在接触甲基汞后接受了换血治疗。其中两名出现严重中毒症状,另一名临床症状正常,但血液汞浓度很高。换血不仅使汞从血液中清除,也从其他组织中清除。据估计,两小时换血所清除的汞平均量为体内汞负荷的6%,而正常排泄过程在24小时内清除的汞量为体内汞负荷的1%。两名中毒患者的临床状况没有显著改善。在对他们家中进行随访时,观察到运动能力和功能有一些改善。

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