Møller P
Acta Otolaryngol Suppl. 1984;414:171-7. doi: 10.3109/00016488409122901.
Tympanosclerosis of the ear drum in children with SOM differs from normal ear drums in children with SOM. In tympanosclerosis the numbers of fibroblasts, fibrocytes and macrophages are increased in lamina propria and in the submucosa. The collagen microfibrils and procollagen filaments have increased in numbers with a partly disorganized pattern. Fibrolysis of microfibrils is conspicuous and hyaline degeneration appears in areas. Calcareous deposits are found scattered to a limited extent in lamina propria and in the submucosa. Profound calcification could only be found in children with tympanosclerosis coexisting with chronic perforation of the ear drum.
分泌性中耳炎（SOM）患儿的鼓膜鼓室硬化与正常SOM患儿的鼓膜不同。在鼓室硬化中，固有层和黏膜下层的成纤维细胞、纤维细胞和巨噬细胞数量增加。胶原微纤维和前胶原纤维数量增加，排列部分紊乱。微纤维的纤维溶解明显，局部出现玻璃样变性。固有层和黏膜下层有少量散在的钙质沉积。只有在鼓膜鼓室硬化合并鼓膜慢性穿孔的患儿中才能发现深度钙化。
