Pasternack G R, Johnson R J, Shin H S
J Immunol. 1978 May;120(5):1567-72.
Tumor cells in a cytostatic state caused by macrophages and antibody were isolated. Such suppressed cells excluded vital dye, incorporated uridine and leucine, and metabolized glucose. They did not, however incorporate thymidine, nor did they resume cell division in culture. During prolonged culture, these cells eventually died. In this system, cytostasis was an all-or-nothing phenomenon at the level of the individual cell. Once in the cytostatic state tumor cells did not resume proliferation.
分离出由巨噬细胞和抗体导致处于细胞抑制状态的肿瘤细胞。这类受抑制的细胞排斥活性染料，摄取尿苷和亮氨酸，并代谢葡萄糖。然而，它们不摄取胸苷，在培养中也不会恢复细胞分裂。在长时间培养过程中，这些细胞最终死亡。在这个系统中，细胞抑制在单个细胞水平上是一种全或无的现象。一旦处于细胞抑制状态，肿瘤细胞就不会恢复增殖。
