Gudmundsson O, Berglund G, Herlitz H, Andersson O, Jonsson O
J Hypertens Suppl. 1983 Dec;1(2):15-7.
Blood pressure (BP), sodium in erythrocytes (IeNa) and transmembrane sodium fluxes were determined in normotensive 30 and 50-year-old men with a family history of hypertension (group H; n = 17 and 11 respectively) and without such history (group C; n = 15 and 26 respectively) during normal salt intake and after four weeks on ordinary diet plus 12 g NaCl daily. The 50-year-old men showed a significant increase in BP and weight during high salt intake while the younger men did not. On normal salt, group H had a significantly higher IeNa than group C in both age groups. In the younger group this was accompanied by a decreased Na efflux rate constant. IeNa decreased significantly in group H in both age groups. The decrease in IeNa and increase in pump activity in group H during high salt intake does not support the existence of a sodium transport inhibitor. The increase in BP in the older group during high salt indicates that age is an important factor in BP response.
对有高血压家族史的30岁和50岁血压正常男性（H组；分别为17例和11例）以及无此家族史的男性（C组；分别为15例和26例），在正常盐摄入期间以及在普通饮食加每日12克氯化钠的四周后，测定了血压（BP）、红细胞内钠（IeNa）和跨膜钠通量。50岁男性在高盐摄入期间血压和体重显著增加，而年轻男性则没有。在正常盐摄入情况下，两个年龄组的H组IeNa均显著高于C组。在较年轻组中，这伴随着钠外流速率常数降低。两个年龄组的H组IeNa均显著下降。高盐摄入期间H组IeNa的下降和泵活性的增加不支持钠转运抑制剂的存在。老年组在高盐摄入期间血压升高表明年龄是血压反应的一个重要因素。
