Beck F, Bianchi G, Dörge A, Rick R, Schramm M, Thurau K
J Hypertens Suppl. 1983 Dec;1(2):38-9.
Electron microprobe analysis was used to determine cellular concentrations of potassium and sodium in renal cortical cells of hypertensive rats of the Milan strain (MHS) and spontaneously hypertensive rats of the stroke prone strain (SHRSP) and their respective controls. Potassium concentrations in proximal and distal tubular cells were similar in both strains of hypertensive rats compared with their normotensive controls. In MHS rats proximal tubular cell sodium concentration was lower than in controls by 3.1 mmol/kg ww, whereas in both proximal and distal tubular cells of SHRSP sodium concentrations were higher than in controls by 5.3 and 4.3 mmol/kg ww, respectively. These results indicate that changes in the transport characteristics of the renal tubular epithelium are a feature of both models of hypertension.
采用电子微探针分析技术测定米兰高血压大鼠（MHS）和易卒中型自发性高血压大鼠（SHRSP）及其相应对照组肾皮质细胞中钾和钠的细胞浓度。与正常血压对照组相比，两种高血压大鼠近端和远端肾小管细胞中的钾浓度相似。在MHS大鼠中，近端肾小管细胞钠浓度比对照组低3.1 mmol/kg湿重，而在SHRSP大鼠的近端和远端肾小管细胞中，钠浓度分别比对照组高5.3和4.3 mmol/kg湿重。这些结果表明，肾小管上皮转运特性的改变是两种高血压模型的一个特征。
