Raine A E, Roberts A F, Manley B S, Jones J V, Ledingham J G
J Hypertens Suppl. 1983 Dec;1(2):85-7.
We have compared cardiac performance, hypertrophy and sensitivity to calcium and verapamil of hearts of six to nine-month-old spontaneously hypertensive rats (SHR), two-kidney, one clip renal hypertensive rats (RHR) and age-matched controls. Cardiac output and heart rate were measured using an isolated perfused heart preparation. Mean blood pressure (BP) and heart weight were equally increased in SHR and RHR as was optimal left atrial filling pressure. Cardiac output was increased in both SHR and RHR at any given work load; this improvement was seen especially in SHR and at high aortic pressure (160 cm H2O) was significant in SHR but not RHR. In low [Ca2+], 0.6 mM, cardiac output of RHR and controls fell markedly, but changed little in SHR, whereas in high [Ca2+], 5.1 mM, cardiac performance deteriorated in SHR but was improved in RHR and controls. Verapamil 2 X 10(-7) M reduced Ca2+ responsiveness of RHR and controls threefold but had no effect in SHR. The results suggest there may be an abnormality of cardiac calcium utilization in inherited but not in acquired hypertension.
我们比较了6至9个月大的自发性高血压大鼠（SHR）、双肾单夹肾性高血压大鼠（RHR）以及年龄匹配的对照大鼠心脏的心脏功能、肥大情况以及对钙和维拉帕米的敏感性。使用离体灌注心脏标本测量心输出量和心率。SHR和RHR的平均血压（BP）和心脏重量均同等增加，最佳左心房充盈压也是如此。在任何给定的工作负荷下，SHR和RHR的心输出量均增加；这种改善在SHR中尤为明显，在高主动脉压（160 cm H2O）时，SHR的心输出量显著增加，而RHR则不然。在低钙浓度（0.6 mM）时，RHR和对照大鼠的心输出量明显下降，但SHR变化不大；而在高钙浓度（5.1 mM）时，SHR的心脏功能恶化，而RHR和对照大鼠的心脏功能则得到改善。2×10⁻⁷ M的维拉帕米使RHR和对照大鼠的钙反应性降低了三倍，但对SHR没有影响。结果表明，在遗传性高血压而非获得性高血压中，可能存在心脏钙利用异常。
