Halter F, Meyrat P, Fritsche R, Müller O, Lentze M J, Koelz H R
Scand J Gastroenterol Suppl. 1984;101:47-53.
As shown in a previous study, intragastric administration of 16,16-dimethyl prostaglandin E2 (PGE, 100 micrograms/kg t.i.d.) for three weeks induces growth of the gastric mucosa. The present experiments were designed to study the time course of histological changes after intragastric PGE and to test whether a similar effect could be observed after parenteral administration. Significant thickening of the corpus, but not the antral mucosa was observed after 3 days of intragastric treatment with PGE (100 micrograms/kg t.i.d.), whereas after three weeks the effect was more marked in the antrum than in the corpus. At a dose of 25 micrograms/kg t.i.d., intraperitoneal PGE increased the height of antral mucosa to a similar degree as seen after intragastric treatment. DNA synthesis as assessed by autoradiography after administration of 3H-thymidine at the end of the three week PGE treatment was increased both in the gastric corpus and antrum. Preliminary studies in suckling rats provide evidence that intragastric administration of PGE (100 micrograms/kg t.i.d.) from day 7 to 11 accelerates maturation of the gastric mucosa. It is concluded that thickening of gastric mucosa can be induced by both local and systemic administration of PGE and is due, at least in part, to increased proliferation of gastric mucosal cells.
如先前一项研究所显示，胃内给予16,16 - 二甲基前列腺素E2（PGE，100微克/千克，每日三次），持续三周可诱导胃黏膜生长。本实验旨在研究胃内给予PGE后组织学变化的时间进程，并测试经胃肠外给药后是否能观察到类似效果。胃内用PGE（100微克/千克，每日三次）治疗3天后，观察到胃体显著增厚，但胃窦黏膜未增厚，而三周后胃窦的效果比胃体更明显。腹腔内给予PGE，剂量为25微克/千克，每日三次，可使胃窦黏膜高度增加至与胃内给药后相似的程度。在PGE治疗三周结束时给予3H - 胸腺嘧啶核苷后，通过放射自显影评估的DNA合成在胃体和胃窦均增加。对乳鼠的初步研究表明，从第7天至第11天胃内给予PGE（100微克/千克，每日三次）可加速胃黏膜成熟。得出的结论是，局部和全身给予PGE均可诱导胃黏膜增厚，且至少部分是由于胃黏膜细胞增殖增加所致。
