Kjeldsen S E, Forsberg G, Eide I, Aakesson I, Os I, Skjøtø J, Frederichsen P
J Hypertens Suppl. 1984 Dec;2(3):S301-3.
The present study was undertaken to examine the possible relationship between dietary sodium intake and arginine vasopressin (AVP). In 12 normotensive men (aged 23-26 years) urinary AVP excretion decreased from 6.7 +/- 1.0 to 3.9 +/- 0.3 ng/h (P less than 0.01) when sodium excretion by dietary intervention for one week was reduced from 188 +/- 18 to 16 +/- 2 mmol/24 h. At a high sodium intake (300 mmol/day), AVP excretion increased to 10.0 +/- 1.2 ng/h during the first day (P less than 0.01) and remained high throughout one week of sodium load. These results are compatible with a major physiological role of sodium in AVP secretion in man. A sodium-AVP relationship may play a role in the pathogenesis of essential hypertension since recent reports suggest elevated plasma AVP in essential hypertensive states.
本研究旨在探讨膳食钠摄入量与精氨酸加压素（AVP）之间可能存在的关系。在12名血压正常的男性（年龄23 - 26岁）中，通过为期一周的饮食干预使钠排泄量从188±18 mmol/24小时降至16±2 mmol/24小时时，尿AVP排泄量从6.7±1.0 ng/h降至3.9±0.3 ng/h（P<0.01）。在高钠摄入量（300 mmol/天）时，第一天AVP排泄量增加至10.0±1.2 ng/h（P<0.01），并且在钠负荷的整个一周内均保持在较高水平。这些结果与钠在人类AVP分泌中起主要生理作用相一致。由于最近的报告表明原发性高血压状态下血浆AVP升高，钠 - AVP关系可能在原发性高血压的发病机制中起作用。
