Salvati P, Pinciroli G P, Bianchi G
J Hypertens Suppl. 1984 Dec;2(3):S351-3.
Young pre-hypertensive rats of the Milan strain (MHS) have a faster glomerular filtration rate (GFR) and a higher urine flow in vivo than matched normotensive controls (MNS). Kidneys from both MHS and MNS at different ages were perfused in vitro with cell-free artificial medium, in order to further clarify the nature of these differences, in the absence of extrarenal uncontrolled factors. Isolated kidneys from young MHS showed a faster GFR, a larger tubular Na+ reabsorption and urine flow as compared to matched MNS: such differences endured throughout the 2 h of perfusion. These results support an intrinsic kidney abnormality as causing the above described differences between young rats of the two strains. Isolated kidneys from adult MHS showed faster GFR, higher renal perfusion flow and urine flow, yet similar tubular Na+ reabsorption when compared to MNS. Moreover a faster decay in kidney function was observed in the experiments with MHS. The existence of an extrarenal factor(s) correcting the intrinsic MHS kidney abnormality in vivo is suggested, as no differences were reported in kidney function of intact adult animals.
米兰品系（MHS）的年轻高血压前期大鼠在体内的肾小球滤过率（GFR）比配对的正常血压对照大鼠（MNS）更快，尿流量更高。为了在没有肾外未控制因素的情况下进一步阐明这些差异的本质，对不同年龄的MHS和MNS大鼠的肾脏进行了无细胞人工培养基的体外灌注。与配对的MNS相比，来自年轻MHS的离体肾脏显示出更快的GFR、更大的肾小管钠重吸收和尿流量：这些差异在整个2小时的灌注过程中持续存在。这些结果支持肾脏内在异常导致了上述两种品系年轻大鼠之间的差异。与MNS相比，来自成年MHS的离体肾脏显示出更快的GFR、更高的肾灌注流量和尿流量，但肾小管钠重吸收相似。此外，在MHS的实验中观察到肾功能的衰退更快。由于完整成年动物的肾功能没有差异，提示存在一种肾外因素在体内纠正了MHS肾脏的内在异常。
