Svensson A, Sigström L, Anderscht B, Hansson L
J Hypertens Suppl. 1984 Dec;2(3):S473-5.
Thirty-seven children aged 6-16 years were studied. Their mothers had a history of previous pre-eclampsia or hypertension in pregnancy on average 10.4 years earlier and had later developed sustained hypertension. Blood pressure in these children was significantly higher than in an age-matched control group (125/71 versus 113/64 mmHg, P less than 0.001). Intracellular Na+ in erythrocytes were not elevated, on the contrary the Na+/K+ ratio was significantly lower than in an age- and sex-matched control group (0.095 versus 0.103, P less than 0.05). Thus women with hypertension in pregnancy who later developed sustained essential hypertension have children with elevated blood pressures at an early age. The observation that the erythrocyte Na+/K+ ratio is reduced in such children suggests that the rise in intracellular Na+ commonly described in essential hypertension is not a primary event.
对37名6至16岁的儿童进行了研究。他们的母亲平均在10.4年前有过先兆子痫或孕期高血压病史，后来发展为持续性高血压。这些儿童的血压明显高于年龄匹配的对照组（125/71 mmHg对113/64 mmHg，P<0.001）。红细胞内的Na+没有升高，相反，Na+/K+比值明显低于年龄和性别匹配的对照组（0.095对0.103，P<0.05）。因此，孕期患高血压且后来发展为持续性原发性高血压的女性所生子女在幼年时血压升高。在这些儿童中观察到红细胞Na+/K+比值降低，这表明在原发性高血压中常见的细胞内Na+升高不是一个原发性事件。
