Semplicini A, Ambrosio G B, Rigon E, Dissegna L, Zamboni S, Rossi G, Pessina A C, Dal Palù C
Clinica Medica I, University of Padua, Italy.
J Hypertens Suppl. 1985 Dec;3(3):S61-3.
An increase in intra-erythrocytic sodium (IENa) content has been proposed as a genetic marker of essential hypertension. Intra-erythrocytic sodium was studied using hypotonic lysis and flame photometry after four washings with isotonic MgCl2 in 240 normotensive subjects (aged 10-45 years) on a free diet with (F+, 121 patients) or without (F-, 119 patients) hypertensive parents, recruited from a random sample of the general population. Systolic blood pressure was significantly higher in males F+ than in males F- (130 +/- 2 versus 125 +/- 2 mmHg, mean +/- s.e.m., P < 0.05), while IENa did not differ. In contrast, intra-erythrocytic potassium content (IEK) was significantly lower and red cell sodium potassium (Na:K) ratio significantly higher in F+ than F-. This might reflect decreased NaK pump activity, or increased membrane permeability to cations which causes increased K leakage. No differences in blood pressure, IENa or IEK showed in female F+ versus F-. It is concluded that IENa is not a genetic marker of hypertension, and that it is probably influenced by exogenous factors. Being associated with differences in blood pressure, the abnormalities of IEK and Na:K ratio might be pathogenetically linked to an early increase in blood pressure.
红细胞内钠（IENa）含量增加被认为是原发性高血压的一个遗传标志物。在240名血压正常的受试者（年龄10 - 45岁）中，采用低渗溶血法和火焰光度法，在以等渗氯化镁洗涤4次后，对自由饮食且有（F +，121例患者）或无（F -，119例患者）高血压父母的受试者进行红细胞内钠的研究，这些受试者是从一般人群的随机样本中招募的。男性F +的收缩压显著高于男性F -（130±2对125±2 mmHg，均值±标准误，P < 0.05），而IENa无差异。相反，F +组的红细胞内钾含量（IEK）显著低于F -组，红细胞钠钾（Na:K）比值显著高于F -组。这可能反映了钠钾泵活性降低，或膜对阳离子的通透性增加导致钾泄漏增加。女性F +与F -在血压、IENa或IEK方面无差异。得出的结论是，IENa不是高血压的遗传标志物，且可能受外源性因素影响。IEK和Na:K比值的异常与血压差异相关，可能在发病机制上与血压早期升高有关。
