Halpert R D, Laufer I, Thompson J J, Feczko P J
AJR Am J Roentgenol. 1983 May;140(5):927-30. doi: 10.2214/ajr.140.5.927.
Three cases of patients with esophageal involvement by scleroderma, chronic reflux esophagitis, and adenocarcinoma of the distal esophagus are presented. An underlying columnar metaplasia (Barrett esophagus) was identified in two patients and postulated in the third. It is believed that scleroderma patients with symptomatic chronic gastroesophageal reflux should be investigated for Barrett epithelium. If it is present, these patients should be followed and considered as having an increased risk for development of adenocarcinoma of the esophagus.
本文报告了3例硬皮病累及食管、慢性反流性食管炎和食管远端腺癌患者。2例患者发现有潜在的柱状上皮化生（巴雷特食管），第3例推测有该病变。据信，有症状性慢性胃食管反流的硬皮病患者应检查是否存在巴雷特上皮。如果存在，这些患者应接受随访，并被视为发生食管腺癌的风险增加。
