Eng C, Spechler S J, Ruben R, Li F P
CRC Human Cancer Genetics Research Group, University of Cambridge, United Kingdom.
Cancer Epidemiol Biomarkers Prev. 1993 Jul-Aug;2(4):397-9.
Barrett esophagus was found in seven members of a single family. Two of these patients also had adenocarcinoma of the gastroesophageal junction. Among family members who did not have Barrett epithelium, one had esophageal ulcerations with dysplasia in squamous epithelium and another had an esophageal stricture. The pattern of involvement suggests autosomal dominant inheritance of Barrett esophagus and/or gastroesophageal reflux disease in this family, with a strong predisposition for adenocarcinoma of the esophagus.
在一个家族的七名成员中发现了巴雷特食管。其中两名患者还患有胃食管交界腺癌。在没有巴雷特上皮的家族成员中，一人有食管溃疡伴鳞状上皮发育异常，另一人有食管狭窄。受累模式提示该家族中巴雷特食管和/或胃食管反流病为常染色体显性遗传，且有患食管癌的强烈倾向。
