Brouet J C, Vainchenker W, Blanchard D, Testa U, Cartron J P
Eur J Immunol. 1983 Apr;13(4):350-2. doi: 10.1002/eji.1830130416.
The Tn (or polyagglutinability) syndrome corresponds to a human nonmalignant acquired condition which results from a somatic mutation occurring at the level of bone marrow stem cells. This model offers therefore a unique opportunity to study the contribution of multipotential stem cells to the maintenance of cells from the lymphoid lineage. We found that the Tn mutation is expressed by both myeloid and lymphoid mature blood cells. Whereas a large proportion of surface IgM-bearing B cells carry the Tn mutation, only a small percentage of T cells and IgA- or IgG-bearing B cells are defective, showing that under physiological conditions the penetration of stem cells into the various myeloid and lymphoid compartments is variable.
Tn（或多凝集性）综合征对应于一种人类非恶性获得性疾病，它由骨髓干细胞水平发生的体细胞突变引起。因此，该模型为研究多能干细胞对淋巴系细胞维持的贡献提供了独特的机会。我们发现Tn突变在髓系和淋巴系成熟血细胞中均有表达。虽然大部分带有表面IgM的B细胞携带Tn突变，但只有一小部分T细胞以及带有IgA或IgG的B细胞存在缺陷，这表明在生理条件下，干细胞向各个髓系和淋巴系区室的渗透情况是可变的。
