MDP及其佐剂活性类似物对豚鼠成纤维细胞产生胸腺细胞激活因子的刺激作用。
Stimulating effect of MDP and its adjuvant-active analogues on guinea pig fibroblasts for the production of thymocyte-activating factor.
作者信息
Iribe H, Koga T, Kotani S, Kusumoto S, Shiba T
出版信息
J Exp Med. 1983 Jun 1;157(6):2190-5. doi: 10.1084/jem.157.6.2190.
Abstract
Synthetic muramyl dipeptide (MDP) could stimulate skin fibroblasts of the guinea pig to produce thymocyte-activating factor, which augments the proliferative response of thymocytes to phytohemagglutinin (PHA). Adjuvant-active analogues of MDP also stimulated fibroblasts to produce the factor, whereas adjuvant-inactive analogues failed to do so. Thus a marked parallelism was found between adjuvant activity of these compounds and the stimulating effect on fibroblasts. Thymocyte-activating factor derived from MDP-stimulated fibroblasts was found in the fraction of mol wt 30,000-60,000 by gel filtration on a Sephacryl S-200 column. Furthermore, this factor did not exhibit T cell growth factor activity.
摘要
合成的胞壁酰二肽（MDP）可刺激豚鼠皮肤成纤维细胞产生胸腺细胞激活因子，该因子可增强胸腺细胞对植物血凝素（PHA）的增殖反应。MDP的佐剂活性类似物也刺激成纤维细胞产生该因子，而佐剂无活性的类似物则不能。因此，在这些化合物的佐剂活性与对成纤维细胞的刺激作用之间发现了明显的平行关系。通过在Sephacryl S - 200柱上进行凝胶过滤，发现源自MDP刺激的成纤维细胞的胸腺细胞激活因子存在于分子量为30,000 - 60,000的组分中。此外，该因子不表现出T细胞生长因子活性。
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本文引用的文献
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