通过外膜蛋白亚型分析记录的b型流感嗜血杆菌感染的医院内传播。

Nosocomial spread of Haemophilus influenzae type b infection documented by outer membrane protein subtype analysis.

作者信息

Barton L L, Granoff D M, Barenkamp S J

出版信息

J Pediatr. 1983 Jun;102(6):820-4. doi: 10.1016/s0022-3476(83)80005-5.

Abstract

This report provides evidence of nosocomial transmission of Haemophilus influenzae type b infection between two children in an acute care hospital. In the past, transmission of infection between these children would have gone unrecognized, because the isolates from the respective cases differed in susceptibility to ampicillin. However, the outer membrane protein profile of the two isolates was identical and has previously been observed in less than 2% of type b Haemophilus isolates from patients with invasive disease in the St. Louis area. Thus the likelihood is very low that these two children were both infected with this strain by chance alone (P less than 0.0004). From previous experience, the risk of transmission of Haemophilus in an acute care setting would appear to be very low. However, nosocomial transmission may occasionally occur.

摘要

本报告提供了在一家急症医院中，两名儿童之间发生b型流感嗜血杆菌感染的医院内传播的证据。过去，这些儿童之间的感染传播可能未被识别，因为来自各自病例的分离株对氨苄西林的敏感性不同。然而，这两个分离株的外膜蛋白谱相同，且此前在圣路易斯地区侵袭性疾病患者的b型嗜血杆菌分离株中观察到的比例不到2%。因此，这两名儿童仅是偶然感染该菌株的可能性非常低（P小于0.0004）。根据以往经验，在急症环境中流感嗜血杆菌传播的风险似乎非常低。然而，医院内传播可能偶尔会发生。