Dumbrille-Ross A, Tang S W
Life Sci. 1983 Jun 6;32(23):2677-84. doi: 10.1016/0024-3205(83)90360-0.
The effect of repeated treatment (28 day) with D-fenfluramine, a serotonin (5HT) releaser, L-tryptophan, a 5HT precursor, or fluoxetine, a 5HT uptake inhibitor, on 3H-5HT and 3H-spiperone binding in the rat cerebral cortex was investigated. Treatment with fenfluramine and fluoxetine caused a significant decrease in the number of 3H-5HT binding sites (Bmax). Fenfluramine also decreased binding of 3H-spiperone in the cortex, but fluoxetine treatment increased this binding. Treatment with L-tryptophan produced no change in the binding of either 3H-5HT or of 3H-spiperone significantly. The data show that manipulation of synaptic 5HT concentration does not always result in parallel changes in S1 and S2 receptors. This suggests that the 5HT S1 and S2 receptors may be subject to different regulatory mechanisms.
研究了血清素（5-羟色胺，5HT）释放剂D-芬氟拉明、5HT前体L-色氨酸或5HT摄取抑制剂氟西汀重复治疗（28天）对大鼠大脑皮层中3H-5HT和3H-螺哌隆结合的影响。芬氟拉明和氟西汀治疗导致3H-5HT结合位点（Bmax）数量显著减少。芬氟拉明还降低了皮层中3H-螺哌隆的结合，但氟西汀治疗增加了这种结合。L-色氨酸治疗对3H-5HT或3H-螺哌隆的结合均未产生显著变化。数据表明，突触5HT浓度的调控并不总是导致S1和S2受体发生平行变化。这表明5HT S1和S2受体可能受到不同的调节机制。
