Hall H, Wedel I
J Neural Transm. 1985;64(2):129-43. doi: 10.1007/BF01245974.
The effects of long-term treatment of rats with alaproclate and amiflamine on the number and kinetics of 5-HT1 and 5-HT2 binding sites were investigated using in vitro receptor binding techniques. Some other studies have reported down-regulatory effects of alaproclate and amiflamine on 5-HT2 binding sites in certain regions of the rat forebrain, but no such effects could be detected in the present study. Induction of a high-affinity binding site for 3H-5-HT after long-term antidepressant treatment, as has been reported elsewhere, was not obtained in the present study. The results are compared to the effects obtained by treatment of rats with para-chloroamphetamine (PCA), which depletes the presynaptic neurons of monoamines. These different types of treatment do not cause any change in the binding properties of the specific 5-HT binding sites. It is thus concluded that such manipulations of the presynaptic 5-HT neurons do not affect the postsynaptic 5-HT1 and 5-HT2 binding sites.
运用体外受体结合技术，研究了用 alaproclate 和阿米氟胺对大鼠进行长期治疗，对 5 - HT1 和 5 - HT2 结合位点数量及动力学的影响。其他一些研究报道了 alaproclate 和阿米氟胺对大鼠前脑某些区域 5 - HT2 结合位点有下调作用，但在本研究中未检测到此类作用。如其他地方所报道的，长期抗抑郁治疗后诱导出 3H - 5 - HT 的高亲和力结合位点，在本研究中也未得到。将这些结果与用对氯苯丙胺（PCA）处理大鼠所获得的结果进行比较，PCA 可耗尽单胺类的突触前神经元。这些不同类型的处理不会导致特异性 5 - HT 结合位点的结合特性发生任何变化。因此得出结论，对突触前 5 - HT 神经元的此类操作不会影响突触后 5 - HT1 和 5 - HT2 结合位点。
