Joseph S A, Knigge K M
Neurosci Lett. 1983 Feb 21;35(2):135-41. doi: 10.1016/0304-3940(83)90540-2.
Using antiserum generated against the synthetic CRF1-41 we have immunocytochemically localized perikarya and processes in rat brain. Areas observed to have particularly dense accumulation of CRF-ir cells were in the extra-hypothalamic areas of nucleus accumbens septi, nucleus of the stria terminalis, the medial preoptic region, and the central amygdaloid nucleus. Within the hypothalamus cell bodies were scattered throughout the anterior hypothalamic region and densely packed in the paraventricular nucleus. Fibers appear most dense in the lateral septal region and throughout the external layer of the median eminence.
利用针对合成的促肾上腺皮质激素释放因子1 - 41产生的抗血清，我们通过免疫细胞化学方法在大鼠脑中定位了神经细胞体及其突起。观察到促肾上腺皮质激素释放因子免疫反应阳性（CRF-ir）细胞特别密集的区域位于伏隔核隔区、终纹床核、内侧视前区和中央杏仁核等下丘脑外区域。在下丘脑内，细胞体散在于下丘脑前部区域，而在室旁核中则密集分布。纤维在外侧隔区和正中隆起的外层最为密集。
