促性腺激素给药期间大鼠睾丸类固醇代谢的改变。

Modification of testicular steroid metabolism in the rat during gonadotrophin administration.

作者信息

Lacroix E, Eechaute W, Leusen I

出版信息

Arch Int Physiol Biochim. 1976 Dec;84(5):911-4. doi: 10.3109/13813457609069453.

Abstract

The administration of human chorionic gonadotrophins to adult rats stimulates the formation of testosterone, 7alpha-hydroxy-testosterone and 5alpha-androstanediol in incubated testes. When the gonadotrophins are injected for several days, the testosterone formation is maintained at a high level; however, the transformation to 7alpha-hydroxy-testosterone decreases progressively to subcontrol levels, while 5alpha-androstanediol is produced in greater amounts.

摘要

给成年大鼠注射人绒毛膜促性腺激素可刺激孵育睾丸中睾酮、7α-羟基睾酮和5α-雄甾二醇的形成。当连续数天注射促性腺激素时，睾酮的形成维持在较高水平；然而，向7α-羟基睾酮的转化逐渐降低至低于对照水平，而5α-雄甾二醇的生成量则增加。