Maestroni G J, Pierpaoli W, Zinkernagel R M
Immunobiology. 1983 May;164(5):417-29. doi: 10.1016/s0171-2985(83)80037-0.
Long-lived, GVHD-free, H-2 incompatible haemopoietic chimeras (P1 leads to P2) were constructed transfusing unmanipulated bone marrow cells together with recently identified marrow-regulating factors (MRF) in lethally irradiated recipients. The chimeric tolerance of P1 leads to P2 chimeras proved to be adoptively untransferable. Another peculiar property of established P1 leads to P2 allochimeras was their ability to "suppress" or reject passively transfused immunocompetent P1 or P2 lymphocytes. Even this "suppression" appeared to be untransferable and to operate in the chimera only in a fashion dependent upon the age of the established chimeras. This chimeric "unidentified suppressive principle" seems not to follow familiar immunologic lines. A relationship with the mechanism of chimeric tolerance is suggested.
通过向经致死性照射的受体输注未经处理的骨髓细胞以及最近鉴定出的骨髓调节因子（MRF），构建了寿命长、无移植物抗宿主病（GVHD）、H-2不相容的造血嵌合体（P1到P2）。事实证明，P1到P2嵌合体的嵌合耐受性不能通过过继转移。已建立的P1到P2同种嵌合体的另一个独特特性是它们能够“抑制”或被动排斥经免疫的P1或P2淋巴细胞的输注。即使这种“抑制”似乎也不能转移，并且仅以依赖于已建立嵌合体年龄的方式在嵌合体内起作用。这种嵌合的“未鉴定的抑制原理”似乎并不遵循熟悉的免疫学途径。有人提出了它与嵌合耐受性机制的关系。
