人类白细胞抗原（HLA）抗原以及淋巴细胞对某些药物和植物血凝素（PHA）的反应性。

HLA antigens and the reactivity of lymphocytes to some drugs and PHA.

作者信息

Scorza-Smeraldi R, Sabbadini Villa M G, Fabio G, Bonara P, Vanoli M, Resele L, Zanussi C

出版信息

Int J Immunopharmacol. 1983;5(2):145-9. doi: 10.1016/0192-0561(83)90006-1.

Abstract

Peripheral blood lymphocytes from 15 healthy subjects, selected on the basis of their HLA types, were cultured in vitro in the presence of PHA and of a number of drugs which bind adrenergic or dopaminergic receptors (dopamine, norepinephrine, chlorpromazine, haloperidol, propranolol and apomorphine). The results obtained are consistent with an interference between HLA-A1 and cross-reacting specificities and the effect explained by these drugs on the lymphocyte activation by PHA. The possibility is suggested that HLA-A1 and cross-reacting antigens interfere with the binding of such drugs to the cell membrane receptors.

摘要

从15名根据其HLA类型挑选出的健康受试者身上获取外周血淋巴细胞，将其在体外培养，培养环境中有PHA以及多种能与肾上腺素能或多巴胺能受体结合的药物（多巴胺、去甲肾上腺素、氯丙嗪、氟哌啶醇、普萘洛尔和阿扑吗啡）。所获结果表明HLA - A1与交叉反应特异性之间存在干扰，且这些药物对PHA介导的淋巴细胞激活的影响可以由此得到解释。这提示了一种可能性，即HLA - A1和交叉反应抗原会干扰此类药物与细胞膜受体的结合。