抗人白细胞抗原抗体与氯氮平代谢物之间的干扰。
Interference between anti-HLA antibodies and CPZ metabolites.
作者信息
Smeraldi E, Scorza-Smeraldi R, Fabio G, Negri F
出版信息
Psychopharmacology (Berl). 1980 Jan;67(1):87-9. doi: 10.1007/BF00427600.
PMID:6768083
Abstract
The interference of chlorpromazine (CPZ) and several preincubated CPZ metabolites on the lymphocyte absorption of antibodies directed against HLA-A1 and other nonrelated HLA specificities were investigated. Both CPZ and metabolites 7-OH-, Nor1-, and Nor2-CPZ were found to interfere with the specific absorption of anti-HLA-A1 antibodies. The meaning of such a result is discussed.
摘要
研究了氯丙嗪（CPZ）及其几种预孵育代谢产物对针对HLA - A1及其他不相关HLA特异性抗体的淋巴细胞吸收的干扰作用。发现CPZ及其代谢产物7 - 羟基 - CPZ、去甲氯丙嗪1和去甲氯丙嗪2均干扰抗HLA - A1抗体的特异性吸收。并对这一结果的意义进行了讨论。
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