Granoff D M, Squires J E, Munson R S, Suarez B
J Pediatr. 1983 Aug;103(2):185-91. doi: 10.1016/s0022-3476(83)80342-4.
Siblings of patients with type b Haemophilus influenzae meningitis are at increased risk of developing Haemophilus disease. We immunized 26 healthy siblings and 25 control subjects using a vaccine containing the type b polysaccharide capsule (10 micrograms PRP) and pertussis vaccine (4 opacity units) (Lederle Laboratories) to determine whether siblings of patients with Haemophilus meningitis had an impaired antibody response to PRP. Using two intramuscular injections one month apart, we found that the siblings had a lower response to PRP. One month after the second injection, 12 of 24 of the siblings had serum concentrations of anticapsular (PRP) antibody thought to be sufficient to confer protection against Haemophilus disease (greater than or equal to 300 ng/ml), compared with 19 of 24 of the control children tested (50% vs 79%, P = 0.035 by chi-square analysis). In comparison with the normal controls, the siblings produced significantly less IgG anti-PRP antibody but similar amounts of IgM. The impaired responsiveness to PRP was most evident among the 16 children born after their sibling had meningitis and who were not known to have been exposed to type b Haemophilus infection previously. These data indicate that siblings of some patients with type b Haemophilus meningitis have reduced ability to form IgG anti-PRP antibody, which may be associated with increased susceptibility to Haemophilus disease.
b型流感嗜血杆菌脑膜炎患者的兄弟姐妹患嗜血杆菌病的风险增加。我们使用一种含有b型多糖荚膜（10微克PRP）和百日咳疫苗（4个不透明度单位）的疫苗（Lederle实验室）对26名健康的兄弟姐妹和25名对照受试者进行免疫，以确定患嗜血杆菌脑膜炎患者的兄弟姐妹对PRP的抗体反应是否受损。通过间隔一个月进行两次肌肉注射，我们发现这些兄弟姐妹对PRP的反应较低。第二次注射一个月后，24名兄弟姐妹中有12名的抗荚膜（PRP）抗体血清浓度被认为足以提供针对嗜血杆菌病的保护（大于或等于300纳克/毫升），而在接受测试的24名对照儿童中有19名（50%对79%，经卡方分析P = 0.035）。与正常对照组相比，这些兄弟姐妹产生的IgG抗PRP抗体明显较少，但IgM的量相似。对PRP反应受损在其兄弟姐妹患脑膜炎后出生且此前未知曾接触b型流感嗜血杆菌感染的16名儿童中最为明显。这些数据表明，一些b型流感嗜血杆菌脑膜炎患者的兄弟姐妹形成IgG抗PRP抗体的能力降低，这可能与对嗜血杆菌病易感性增加有关。
