虫草素（3'-脱氧腺苷）对耐辐射微球菌DNA中5,6-二羟基-二氢胸腺嘧啶型产物切除修复的影响。
Effect of cordycepin(3'-deoxyadenosine) on excision repair of 5,6-dihydroxy-dihydrothymine-type products from the DNA of Micrococcus radiodurans.
作者信息
Patil M S, Tundo V J, Locher S E, Hariharan P V
出版信息
Radiat Res. 1983 Jul;95(1):205-10.
Cordycepin(3'-deoxyadenosine), a nucleoside analog, has been shown to enhance radiation-induced cell killing. In an effort to elucidate the possible mechanism for enhancement of cell killing, the effect of cordycepin on the excision repair of radiation-induced 5,6-dihydroxy-dihydrothymine-type (t') products from the DNA of wild type Micrococcus radiodurans was investigated. The capacity of M. radiodurans to excise nondimeric (t') products from its DNA was significantly impaired after cordycepin treatment. The results suggest that the increased radiation sensitivity of cordycepin-treated cells could be due to alterations in cellular processes that repair DNA damage.
虫草素（3'-脱氧腺苷），一种核苷类似物，已被证明能增强辐射诱导的细胞杀伤作用。为了阐明增强细胞杀伤作用的可能机制，研究了虫草素对野生型耐辐射微球菌DNA中辐射诱导的5,6-二羟基-二氢胸腺嘧啶型（t'）产物切除修复的影响。经虫草素处理后，耐辐射微球菌从其DNA中切除非二聚体（t'）产物的能力显著受损。结果表明，经虫草素处理的细胞辐射敏感性增加可能是由于修复DNA损伤的细胞过程发生了改变。
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